Click here to enlarge imageThe bacteria also produce bacteriocins (antibiotic peptides) and ferment harmful acids and help prevent pathogenic bacteria from colonizing the gastrointestinal tract. Given their importance, it's hardly surprising that any disruption (antibiotics, for example) allows opportunistic pathogens to cause a wide range of health problems (see Table 2).
We're not born with our symbiotes. Babies have to acquire them from maternal milk and the gut microflora isn't stable until after weaning. Bottle–fed children typically have higher proportions of pathogenic bacteria than breast–fed children. Early antibiotics can disrupt a healthy gut microflora for years afterward.
Colonic bacteria provide us with essential nutrients like biotin, folate, and vitamin K, promote growth, and fight infections. Sometimes, because of human genetic mutations, our immune systems mistake good intestinal bacteria for bad, resulting in the intestinal inflammation characteristic of Crohn's disease, ulcerative colitis, and inflammatory bowel disease. It's also suspected that an atypical gut microflora can liberate toxins from foods and cause diseases such as Tourette's syndrome, Type 1 diabetes, and ADD.
So, with 100 trillion gut bacteria, how does our immune system know which bacteria are good and which are bad? Most bacteria wind up in the colon because the stomach and small intestine are coated with a thick mucus and waves of peristalsis move them quickly along. The colon is the main interface between the immune system and our stomach's bacteria. It contains 75% of the body's lymph glands and 80% of the B cells that produce antibodies and immunoglobulin A that selectively neutralize pathogenic proteins and toxins.