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FluoroCal by Bisco: A great option for relieving dentinal hypersensitivity

Nov. 23, 2021
FluoroCal from Bisco—a xylitol and tricalcium phosphate containing 5% sodium fluoride varnish—is a fresh approach to addressing dentinal hypersensitivity.

As research continues to clarify that, in fact, not all fluoride varnish applications are equal,1 the question becomes: How can we ensure we are carefully researching and subsequently selecting an optimal means of delivering fluoride to our patients?

Introducing FluoroCal from Bisco—a xylitol and tricalcium phosphate containing 5% sodium fluoride varnish with a fresh approach to addressing dentinal hypersensitivity. New to the market, FluoroCal provides excellent clinical benefits. Made without gluten, dairy, or dairy proteins, FluoroCal induces fluorapatite which, in turn, helps strengthen tooth enamel while providing patient-pleasing esthetics and quick product application with a refreshing spearmint flavor.

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Dentinal hypersensitivity affects up to 30% of adult patients.2 The hydrodynamic theory indicates that dentinal hypersensitivity likely originates from exposure of dentinal tubules permitting the fluid movement of odontoblastic processes leading to pulpal stimulation.3 FluoroCal begins by penetrating and then occluding dentinal tubules providing immediate relief of hypersensitivity.

Protection from demineralization

As the strengthened fluorapatite4 helps to strengthen tooth enamel, the formulated tricalcium phosphate allows for enhanced protection from demineralization, as studies have demonstrated that fluoride varnishes containing tri-calcium phosphate not only support strong enamel, but subsequently inhibit the progression of primary enamel lesions.5

Sustained release

Perhaps FluoroCal’s optimal performance is due in part to the fluoride and calcium release as tested in deionized water. Of note: this product demonstrates one of the highest stained fluoride release levels among its competitors and continues to increase in fluoride release concentration at 24 hours after application.6 Additionally, specimen samples indicate that FluoroCal provides the most fluoride-rich enamel in surface specimen samples following application.6 Finally, targeted and sustained release of calcium is high in FluoroCal, noting a steady incline in calcium release seen at 24 hours following application.6,7


Evidence suggests that treatment acceptance is more likely if providers value the information they are sharing.8 Perhaps fluoride toxicity concerns go beyond antifluoridationists and fears of out-of-pocket spending and truly lie in our own responsibility to strengthen our understanding of advancements in the fluoride varnish market. Investing in the best product will empower us in our conversations with patients who can benefit from products like FluoroCal from Bisco. And who knows? Perhaps the right product will turn up the heat on our bottom line. 

Learn more about Bisco’s FluoroCal and why it is the optimal fluoride varnish medicament for your dental patients at 

Editor's note: This article appeared in the November 2021 print edition ofRDH.


  1. Arnold M. Are fluoride varnishes really all the same? Dental Products Report. July 19, 2017.
  2. Addy M. Etiology and clinical implications of dentine hypersensitivity. Dent Clin North Am. 1990;34(3):503-514.
  3. Walters PA. Dentinal hypersensitivity: a review. J Contemp Dent Pract. 2005;6(2):107-117.
  4. Petersson LG. The role of fluoride in the preventive management of dentin hypersensitivity and root caries. Clin Oral Investig. 2013;17(Suppl 1):S63-S71. doi:10.1007/s00784-012-0916-9
  5. Rirattanapong P, Vongsavan K, Saengsirinavin C, Pornmahala T. Effect of fluoride varnishes containing tri-calcium phosphate sources on remineralization of initial primary enamel lesions. Southeast Asian J Trop Med Public Health. 2014;45(2):499-504.
  6. Bisco internal documents.
  7. Sedlacek T, Yu E, Nunez R, Suh BI. Comparison of enamel fluoride uptake from five fluoride-containing topical treatment products. On J Dent & Oral Health. 2020;3(5). doi:10.33552/OJDOH.2020.03.000571
  8. Falk E, Scholz C. Persuasion, influence, and value: perspectives from communication and social neuroscience. Annu Rev Psychol. 2018;69:329-356. doi:10.1146/annurev-psych-122216-011821